Clenbuterol is a medicine used in medicine to treat asthma. In recent years, Clenbuterol has been widely used in bodybuilding and fitness due to its ability to burn fat, which is why it is often used by athletes for weight loss and surgery. Clenbuterol courses often include thyroxine and ketotifen to accelerate weight loss. Clenbuterol is not associated with anabolic steroids and belongs to the group of adrenergic agonists that obtain their physiological effects by stimulating beta-2-adrenergic receptors, which activates the sympathetic nervous system and triggers lipolysis. A prescription is required to purchase the drug. It can be prescribed to girls without the risk of developing androgenic side effects typical of anabolic steroids.
Elimination half-life: 36 hours.
WADA has banned the use of Clenbuterol in sports since 1992. Standard anti-doping tests usually respond to a urine concentration of 5-10 ng / l, which is observed 4-5 days after the last dose. More sensitive tests extend the detection time of clenbuterol to 2-3 weeks or more (1-2 ng / l). The drug accumulates in adipose tissue and can be released more actively during exercise or competition.
One possible way to take Clenbuterol into an athlete’s body may be meat, as in some countries (China, Mexico) it is used to increase the weight of fatty animals.
Several scientific articles report repeated use of clenbuterol in athletic fat loss.
Mechanism of action
As a beta-2 agonist, clenbuterol acts as a fat burner by binding to type 2 beta receptors in the adipose and muscle tissues of the human body. When Clenbuterol binds to the receptor, a series of biochemical reactions begin, leading to increased synthesis of cAMP (cyclic adenosine monophosphate). cAMP, in turn, activates enzymes that mobilize fatty acids from adipocytes (adipose tissue cells).
The effect of clenbuterol on the beta-2 adrenergic receptors of the presynaptic membrane increases the release of noradrenaline and adrenaline, which has a strong fat-burning effect. Clenbuterol increases the metabolic rate by 20-30% from baseline.
Clenbuterol blocks the action of lipoprotein lipase, making it impossible to store fat in adipose tissue. It affects the beta-2 adrenergic receptors in the central nervous system and improves the secretion of thyroid hormones – the body’s natural fat burners.
The unique property of Clenbuterol is that it is not only a powerful fat burner, but also has a powerful anti-catabolic effect that protects muscles from destruction, which is very important during weight loss and dehydration in bodybuilding. The studies showed that the anticatabolic effect of the drug is due to Ca 2+ blockade and ubiquitin-proteasome-dependent proteolysis.